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Chemical structure of E3 ligase Ligand 8

GC35933

E3 ligase Ligand 8

Also known as (2S)-2-[[(2S,3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid

E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase· E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs· PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins

ChemicalCAS1225383-33-4MW530.61FormulaC31H34N2O6
CAS number
1225383-33-4
Molecular weight
530.61
Formula
C31H34N2O6
Solubility
DMSO： 100 mg/mL (188·46 mM)
InChIKey
DYKHBFJZCIEBJE-PKTNWEFCSA-N
Catalogue number
GC35933
Brand
GLPBIO
Computed properties PubChem CID 138911308 · XLogP 5.1 · TPSA 125 Ų · H-bond donors 4
XLogP
5.1
TPSA
125 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
12
Heavy atoms
39

SMILES CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)O

Computed descriptors from PubChem (CID 138911308), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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