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Chemical structure of CDK4/6-IN-15

GC68848

CDK4/6-IN-15

Also known as 5-[2-[[5-[4-(dimethylamino)piperidin-1-yl]-2-pyridinyl]amino]-5-fluoropyrimidin-4-yl]-N,4-dimethyl-1,3-thiazol-2-amine

CDK4/6-IN-15 is an orally effective and selective CDK4/6 inhibitor· It can effectively inhibit cancer cell growth· CDK4/6-IN-15 blocks the cell cycle in the G1 phase and inhibits phosphorylation of retinoblastoma tumor suppressor protein (Rb) at S780 site and E2 factor (E2F)-regulated gene expression in retinoblastoma tumors

ChemicalCAS2078047-99-9MW442.56FormulaC21H27FN8S
CAS number
2078047-99-9
Molecular weight
442.56
Formula
C21H27FN8S
Solubility
DMSO ： 5 mg/mL (11·30 mM; ultrasonic and warming and heat to 60°C)
InChIKey
NAGFLZVMWVHHLW-UHFFFAOYSA-N
Catalogue number
GC68848
Brand
GLPBIO
Computed properties PubChem CID 135286280 · XLogP 3.6 · TPSA 110 Ų · H-bond donors 2
XLogP
3.6
TPSA
110 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
31

SMILES CC1=C(SC(=N1)NC)C2=NC(=NC=C2F)NC3=NC=C(C=C3)N4CCC(CC4)N(C)C

Computed descriptors from PubChem (CID 135286280), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.