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Chemical structure of CDK4/6-IN-6

GC64802

CDK4/6-IN-6

Also known as (3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(2-hydroxypropan-2-yl)-3-propan-2-ylbenzimidazol-5-yl]pyrimidin-2-yl]amino]oxan-3-ol

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0·6 nM and 13·9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively

ChemicalCAS2380321-51-5MW463.93FormulaC22H27ClFN5O3
CAS number
2380321-51-5
Molecular weight
463.93
Formula
C22H27ClFN5O3
Solubility
DMSO ： 250 mg/mL (538·87 mM; Need ultrasonic)
InChIKey
QYJLBHRAPDJOSO-NVXWUHKLSA-N
Catalogue number
GC64802
Brand
GLPBIO
Computed properties PubChem CID 146219790 · XLogP 2.3 · TPSA 105 Ų · H-bond donors 3
XLogP
2.3
TPSA
105 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
32

SMILES CC(C)N1C2=C(C(=CC(=C2)C3=NC(=NC=C3Cl)N[C@@H]4CCOC[C@H]4O)F)N=C1C(C)(C)O

Computed descriptors from PubChem (CID 146219790), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.