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Chemical structure of ORIC-101

GC65370

ORIC-101

Also known as (8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5·6 nM

ChemicalCAS2222344-98-9MW501.74FormulaC34H47NO2
CAS number
2222344-98-9
Molecular weight
501.74
Formula
C34H47NO2
Solubility
DMSO ： ≥ 100 mg/mL (199·31 mM)
InChIKey
VNLTWJIWEYPBIF-KMSLUKAPSA-N
Catalogue number
GC65370
Brand
GLPBIO
Computed properties PubChem CID 134415769 · XLogP 6.9 · TPSA 40.5 Ų · H-bond donors 1
XLogP
6.9
TPSA
40.5 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
37

SMILES CC(C)N(C)C1=CC=C(C=C1)[C@H]2C[C@]3([C@@H](CC[C@]3(C#CC(C)(C)C)O)[C@H]4[C@H]2[C@H]5CCC(=O)C=C5CC4)C

Computed descriptors from PubChem (CID 134415769), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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