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Chemical structure of NRX-252262

GC65336

NRX-252262

Also known as 4-(2,6-dichlorophenyl)sulfanyl-3-(5,6-dimethoxy-1,3-dihydroisoindole-2-carbonyl)-6-(trifluoromethyl)-1H-pyridin-2-one

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3·8 nM

ChemicalCAS2438637-61-5MW545.36FormulaC23H17Cl2F3N2O4S
CAS number
2438637-61-5
Molecular weight
545.36
Formula
C23H17Cl2F3N2O4S
Solubility
DMSO ： 8·33 mg/mL (15·27 mM; Need ultrasonic)
InChIKey
SPAYLOCXFWJEBL-UHFFFAOYSA-N
Catalogue number
GC65336
Brand
GLPBIO
Computed properties PubChem CID 138319682 · XLogP 4.8 · TPSA 93.2 Ų · H-bond donors 1
XLogP
4.8
TPSA
93.2 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
35

SMILES COC1=C(C=C2CN(CC2=C1)C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)OC

Computed descriptors from PubChem (CID 138319682), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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