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Chemical structure of SRT 1460

GC65019

SRT 1460

Also known as 3,4,5-trimethoxy-N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1·5 value of 2·9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1·5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues

ChemicalCAS925432-73-1MW507.6FormulaC26H29N5O4S
CAS number
925432-73-1
Molecular weight
507.6
Formula
C26H29N5O4S
Solubility
DMSO ： 10 mg/mL (19·70 mM; Need ultrasonic)
InChIKey
SBEWVVLMFLTQFE-UHFFFAOYSA-N
Catalogue number
GC65019
Brand
GLPBIO
Computed properties PubChem CID 24180124 · XLogP 3.5 · TPSA 118 Ų · H-bond donors 2
XLogP
3.5
TPSA
118 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
36

SMILES COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5

Computed descriptors from PubChem (CID 24180124), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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