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Chemical structure of SRT 2183

GC64946

SRT 2183

Also known as N-[2-[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]naphthalene-2-carboxamide

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1·5 value of 0·36 μM· SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels

ChemicalCAS1001908-89-9MW468.57FormulaC27H24N4O2S
CAS number
1001908-89-9
Molecular weight
468.57
Formula
C27H24N4O2S
Solubility
DMSO ： 250 mg/mL (533·54 mM; Need ultrasonic)
InChIKey
MUFSINOSQBMSLE-JOCHJYFZSA-N
Catalogue number
GC64946
Brand
GLPBIO
Computed properties PubChem CID 24180126 · XLogP 5 · TPSA 98.1 Ų · H-bond donors 2
XLogP
5
TPSA
98.1 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
34

SMILES C1CN(C[C@@H]1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5

Computed descriptors from PubChem (CID 24180126), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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