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Chemical structure of SRT2104 (GSK2245840)

GC15109

SRT2104 (GSK2245840)

Also known as 4-methyl-N-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide

SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1), penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and protected against diabetes-induced aortic endothelial dysfunction

ChemicalCAS1093403-33-8MW516.64FormulaC26H24N6O2S2
CAS number
1093403-33-8
Molecular weight
516.64
Formula
C26H24N6O2S2
Solubility
≥ 6·46 mg/mL in DMSO with gentle warming
InChIKey
LAMQVIQMVKWXOC-UHFFFAOYSA-N
Catalogue number
GC15109
Brand
GLPBIO
Computed properties PubChem CID 25108829 · XLogP 4.2 · TPSA 141 Ų · H-bond donors 1
XLogP
4.2
TPSA
141 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
36

SMILES CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CN5C(=CSC5=N4)CN6CCOCC6

Computed descriptors from PubChem (CID 25108829), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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