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Chemical structure of ZXH-1-161

GC64969

ZXH-1-161

Also known as 3-[7-[[2-(2,3-dihydro-1H-inden-5-ylamino)pyrimidin-4-yl]amino]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1·S wild type cells· ZXH-1-161 has selective degradation activity towards GSPT1· ZXH-1-161 can be used for researching multiple myeloma

ChemicalCAS2407654-51-5MW468.51FormulaC26H24N6O3
CAS number
2407654-51-5
Molecular weight
468.51
Formula
C26H24N6O3
Solubility
DMSO ： 250 mg/mL (533·61 mM; Need ultrasonic)
InChIKey
KCIIVRZRNLZKQA-UHFFFAOYSA-N
Catalogue number
GC64969
Brand
GLPBIO
Computed properties PubChem CID 153385170 · XLogP 3 · TPSA 116 Ų · H-bond donors 3
XLogP
3
TPSA
116 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
35

SMILES C1CC2=C(C1)C=C(C=C2)NC3=NC=CC(=N3)NC4=CC=CC5=C4CN(C5=O)C6CCC(=O)NC6=O

Computed descriptors from PubChem (CID 153385170), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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