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Chemical structure of ZX-29

GC64013

ZX-29

Also known as N-[2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]methanesulfonamide

ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2·1 nM, 1·3 nM and 3·9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively· ZX-29 is inactive against EGFR· ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation· ZX-29 also induces protective autophagy and has antitumor effect

ChemicalCAS2254805-62-2MW518.03FormulaC23H28ClN7O3S
CAS number
2254805-62-2
Molecular weight
518.03
Formula
C23H28ClN7O3S
Solubility
DMSO ： 50 mg/mL (96·52 mM; ultrasonic and warming and heat to 60°C)
InChIKey
ATHZZWBANOJUOA-UHFFFAOYSA-N
Catalogue number
GC64013
Brand
GLPBIO
Computed properties PubChem CID 142497299 · XLogP 3.5 · TPSA 120 Ų · H-bond donors 3
XLogP
3.5
TPSA
120 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
8
Heavy atoms
35

SMILES CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl)OC

Computed descriptors from PubChem (CID 142497299), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.