Loading...
Chemical structure of ZYF0033

GC69239

ZYF0033

Also known as 4-[3-[[2-amino-5-[2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]-3-pyridinyl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol

ZYF0033 (HPK1-IN-22, compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM based on its inhibitory effect on MBP protein phosphorylation· ZYF0033 reduces the phosphorylation of SLP76 (serine 376)· ZYF0033 promotes anti-cancer immune response· ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased infiltration of DC, NK cells, and CD107a+CD8+ T cells into tumors but decreased infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells

ChemicalCAS2380300-79-6MW462.61FormulaC26H30N4O2S
CAS number
2380300-79-6
Molecular weight
462.61
Formula
C26H30N4O2S
InChIKey
BJNWUKRWOQERPQ-UHFFFAOYSA-N
Catalogue number
GC69239
Brand
GLPBIO
Computed properties PubChem CID 155905549 · XLogP 3.4 · TPSA 113 Ų · H-bond donors 2
XLogP
3.4
TPSA
113 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES CC(C)(C#CC1=CC=CC(=C1)COC2=C(N=CC(=C2)C3=CN=C(S3)C4CCN(CC4)C)N)O

Computed descriptors from PubChem (CID 155905549), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.