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Chemical structure of KRA-533

GC64558

KRA-533

Also known as 4-[4-[(2-bromoacetyl)amino]butyl]benzoic acid

KRA-533 is a potent KRAS agonist· KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells

ChemicalCAS10161-87-2MW314.18FormulaC13H16BrNO3
CAS number
10161-87-2
Molecular weight
314.18
Formula
C13H16BrNO3
InChIKey
WZQJLTLURXNPQG-UHFFFAOYSA-N
Catalogue number
GC64558
Brand
GLPBIO
Computed properties PubChem CID 270269 · XLogP 2.5 · TPSA 66.4 Ų · H-bond donors 2
XLogP
2.5
TPSA
66.4 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
7
Heavy atoms
18

SMILES C1=CC(=CC=C1CCCCNC(=O)CBr)C(=O)O

Computed descriptors from PubChem (CID 270269), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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