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Chemical structure of MK-0493

GC64427

MK-0493

Also known as N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]ethyl]acetamide

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake

ChemicalCAS455956-93-1MW546.09FormulaC30H38ClF2N3O2
CAS number
455956-93-1
Molecular weight
546.09
Formula
C30H38ClF2N3O2
Solubility
DMSO ： 100 mg/mL (183·12 mM; Need ultrasonic)
InChIKey
ZCWVNCMFYHPHCX-RHLLTPQKSA-N
Catalogue number
GC64427
Brand
GLPBIO
Computed properties PubChem CID 11642422 · XLogP 4.8 · TPSA 52.7 Ų · H-bond donors 1
XLogP
4.8
TPSA
52.7 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
38

SMILES C[C@@H](C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)[C@@H]3CN(C[C@H]3C4=C(C=C(C=C4)F)F)C(C)(C)C)NC(=O)C

Computed descriptors from PubChem (CID 11642422), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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