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Chemical structure of MK-0249

GC31027

MK-0249

Also known as 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one

MK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1·7 nM for human H3

ChemicalCAS862309-06-6MW431.45FormulaC23H24F3N3O2
CAS number
862309-06-6
Molecular weight
431.45
Formula
C23H24F3N3O2
Solubility
DMSO ： 50 mg/mL (115·89 mM; Need ultrasonic)
InChIKey
DDDZBLNULGDPGA-UHFFFAOYSA-N
Catalogue number
GC31027
Brand
GLPBIO
Computed properties PubChem CID 11697697 · XLogP 4.2 · TPSA 45.1 Ų · H-bond donors 0
XLogP
4.2
TPSA
45.1 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
31

SMILES CC1=NC2=CC=CC(=C2C(=O)N1C3=CC=C(C=C3)OCCCN4CCCC4)C(F)(F)F

Computed descriptors from PubChem (CID 11697697), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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