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Chemical structure of MK-0354

GC32464

MK-0354

Also known as 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole

MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1·65/1·08 μM, showed no activation of GPR109b

ChemicalCAS851776-28-8MW176.18FormulaC7H8N6
CAS number
851776-28-8
Molecular weight
176.18
Formula
C7H8N6
Solubility
DMSO ： ≥ 36 mg/mL (204·34 mM)
InChIKey
LTQYSJKGRPGMPO-UHFFFAOYSA-N
Catalogue number
GC32464
Brand
GLPBIO
Computed properties PubChem CID 11159621 · XLogP 0.2 · TPSA 83.1 Ų · H-bond donors 2
XLogP
0.2
TPSA
83.1 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
13

SMILES C1CC2=C(C1)NN=C2C3=NNN=N3

Computed descriptors from PubChem (CID 11159621), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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