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Chemical structure of HIF-2α-IN-4

GC63678

HIF-2α-IN-4

Also known as methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM· HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression· HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing

ChemicalCAS882268-69-1MW287.32FormulaC9H9N3O4S2
CAS number
882268-69-1
Molecular weight
287.32
Formula
C9H9N3O4S2
InChIKey
OOGAPDPPVHJYGJ-KPKJPENVSA-N
Catalogue number
GC63678
Brand
GLPBIO
Computed properties PubChem CID 6375097 · XLogP 2.1 · TPSA 145 Ų · H-bond donors 1
XLogP
2.1
TPSA
145 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
18

SMILES COC(=O)C1=C(C=CS1)N/N=C(\C#N)/S(=O)(=O)C

Computed descriptors from PubChem (CID 6375097), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.