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Chemical structure of AMG131

GC62836

AMG131

Also known as 2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide

AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM

ChemicalCAS315224-26-1MW514.21FormulaC21H12Cl4N2O3S
CAS number
315224-26-1
Molecular weight
514.21
Formula
C21H12Cl4N2O3S
Solubility
DMSO ： 250 mg/mL (486·18 mM; Need ultrasonic)
InChIKey
NMRWDFUZLLQSBN-UHFFFAOYSA-N
Catalogue number
GC62836
Brand
GLPBIO
Computed properties PubChem CID 10229498 · XLogP 6.8 · TPSA 76.7 Ų · H-bond donors 1
XLogP
6.8
TPSA
76.7 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
31

SMILES C1=CC=C2C(=C1)C=C(C=N2)OC3=C(C=C(C=C3Cl)NS(=O)(=O)C4=C(C=C(C=C4)Cl)Cl)Cl

Computed descriptors from PubChem (CID 10229498), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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