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Chemical structure of AMG232

GC15828

AMG232

Also known as 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid

AMG232 (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0·6 nM· AMG232 binds to MDM2 with a Kd of 0·045 nM

ChemicalCAS1352066-68-2MW568.55FormulaC28H35Cl2NO5S
CAS number
1352066-68-2
Molecular weight
568.55
Formula
C28H35Cl2NO5S
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,Ethanol： 30 mg/ml,Ethanol：PBS (pH 7·2)(1：2)： 0·33 mg/ml
InChIKey
DRLCSJFKKILATL-YWCVFVGNSA-N
Catalogue number
GC15828
Brand
GLPBIO
Computed properties PubChem CID 58573469 · XLogP 5.8 · TPSA 100 Ų · H-bond donors 1
XLogP
5.8
TPSA
100 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
37

SMILES CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl

Computed descriptors from PubChem (CID 58573469), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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