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Chemical structure of AMG PERK 44

GC39156

AMG PERK 44

Also known as 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM· AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively· AMG PERK 44 induces autophagy

ChemicalCAS1883548-84-2MW561.07FormulaC34H29ClN4O2
CAS number
1883548-84-2
Molecular weight
561.07
Formula
C34H29ClN4O2
Solubility
DMSO： 25 mg/mL (44·56 mM)
InChIKey
RNAKBTDDCHJCMT-UHFFFAOYSA-N
Catalogue number
GC39156
Brand
GLPBIO
Computed properties PubChem CID 121513867 · TPSA 79.5 Ų · H-bond donors 2 · H-bond acceptors 5
TPSA
79.5 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
41

SMILES CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl

Computed descriptors from PubChem (CID 121513867), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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