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Chemical structure of PF-06869206

GC19289

PF-06869206

Also known as 3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM

ChemicalCAS2227425-05-8MW374.75FormulaC15H14ClF3N4O2
CAS number
2227425-05-8
Molecular weight
374.75
Formula
C15H14ClF3N4O2
Solubility
DMSO ： ≥ 125 mg/mL (333·56 mM)
InChIKey
ATFQBBCQZKVZJN-QMMMGPOBSA-N
Catalogue number
GC19289
Brand
GLPBIO
Computed properties PubChem CID 134159047 · XLogP 1.9 · TPSA 85.2 Ų · H-bond donors 2
XLogP
1.9
TPSA
85.2 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
2
Heavy atoms
25

SMILES CC1=C(C2=C(N1)C(=C(C(=N2)C(F)(F)F)C#N)N3CCO[C@@H](C3)CO)Cl

Computed descriptors from PubChem (CID 134159047), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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