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Chemical structure of (S,R,S)-AHPC

GC62283

(S,R,S)-AHPC

Also known as (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein· (S,R,S)-AHPC can be connected to the ligand for protein (e·g·, BCR-ABL1) by a linker to form PROTACs (e·g·, GMB-475)· GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1·11 μM in Ba/F3 cells

ChemicalCAS1448297-52-6MW430.56FormulaC22H30N4O3S
CAS number
1448297-52-6
Molecular weight
430.56
Formula
C22H30N4O3S
InChIKey
ZLOXMSNKPDWMEF-ZIFCJYIRSA-N
Catalogue number
GC62283
Brand
GLPBIO
Computed properties PubChem CID 89702519 · XLogP 2.1 · TPSA 137 Ų · H-bond donors 3
XLogP
2.1
TPSA
137 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)N)O

Computed descriptors from PubChem (CID 89702519), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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