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Chemical structure of (S,R,S)-AHPC-C8-NH2

GC39790

(S,R,S)-AHPC-C8-NH2

Also known as (2S,4R)-1-[(2S)-2-(9-aminononanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader

ChemicalCAS2341796-79-8MW585.8FormulaC31H47N5O4S
CAS number
2341796-79-8
Molecular weight
585.8
Formula
C31H47N5O4S
Solubility
DMSO : ≥ 100 mg/mL (170·71 mM)
InChIKey
QLJZVMJBYNFUSG-CERRFVOPSA-N
Catalogue number
GC39790
Brand
GLPBIO
Computed properties PubChem CID 138991798 · XLogP 4 · TPSA 166 Ų · H-bond donors 4
XLogP
4
TPSA
166 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
15
Heavy atoms
41

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCN)O

Computed descriptors from PubChem (CID 138991798), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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