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Chemical structure of ON1231320

GC62174

ON1231320

Also known as 6-(2,4-difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0·31 ?M· ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death· ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity

ChemicalCAS1312471-39-8MW467.45FormulaC22H15F2N5O3S
CAS number
1312471-39-8
Molecular weight
467.45
Formula
C22H15F2N5O3S
Solubility
DMSO ： 25 mg/mL (53·48 mM; Need ultrasonic)
InChIKey
ZEHBZHZMQSHZFI-UHFFFAOYSA-N
Catalogue number
GC62174
Brand
GLPBIO
Computed properties PubChem CID 67240318 · XLogP 3.3 · TPSA 116 Ų · H-bond donors 2
XLogP
3.3
TPSA
116 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
33

SMILES CN1C2=NC(=NC=C2C=C(C1=O)S(=O)(=O)C3=C(C=C(C=C3)F)F)NC4=CC5=C(C=C4)NC=C5

Computed descriptors from PubChem (CID 67240318), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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