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Chemical structure of (S,R,S)-AHPC-amido-C5-acid

GC62148

(S,R,S)-AHPC-amido-C5-acid

Also known as 7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-7-oxoheptanoic acid

(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker· (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133

ChemicalCAS2162120-87-6MW572.72FormulaC29H40N4O6S
CAS number
2162120-87-6
Molecular weight
572.72
Formula
C29H40N4O6S
InChIKey
LYAMSRXTXVKKIC-TVZXLZGTSA-N
Catalogue number
GC62148
Brand
GLPBIO
Computed properties PubChem CID 134184033 · XLogP 3 · TPSA 177 Ų · H-bond donors 4
XLogP
3
TPSA
177 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
13
Heavy atoms
40

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCC(=O)O)O

Computed descriptors from PubChem (CID 134184033), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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