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Chemical structure of JHU 37152

GC50681

JHU 37152

Also known as 3-chloro-6-(4-ethylpiperazin-1-yl)-7-fluoro-11H-benzo[b][1,4]benzodiazepine

JHU 37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5nM and 0·5nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively

ChemicalCAS2369979-67-7MW358.85FormulaC19H20ClFN4
CAS number
2369979-67-7
Molecular weight
358.85
Formula
C19H20ClFN4
Solubility
DMSO|35·88|100|ethanol|35·88|100|
InChIKey
NZMZJNNWMSYDNX-UHFFFAOYSA-N
Catalogue number
GC50681
Brand
GLPBIO
Computed properties PubChem CID 139033721 · XLogP 3.5 · TPSA 30.9 Ų · H-bond donors 1
XLogP
3.5
TPSA
30.9 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
25

SMILES CCN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=C2C(=CC=C4)F

Computed descriptors from PubChem (CID 139033721), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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