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Chemical structure of EN219

GC49124

EN219

Also known as 1-[3,5-bis(4-bromophenyl)-3,4-dihydropyrazol-2-yl]-2-chloroethanone

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM· EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination

ChemicalCAS380351-29-1MW456.6FormulaC17H13Br2ClN2O
CAS number
380351-29-1
Molecular weight
456.6
Formula
C17H13Br2ClN2O
Solubility
DMF： 10 mg/ml,DMSO： 5 mg/ml,Ethanol： 1 mg/ml
InChIKey
CXRHMHAKZPJNKS-UHFFFAOYSA-N
Catalogue number
GC49124
Brand
GLPBIO
Computed properties PubChem CID 3413196 · XLogP 4.7 · TPSA 32.7 Ų · H-bond donors 0
XLogP
4.7
TPSA
32.7 Ų
H-bond donors
0
H-bond acceptors
2
Rotatable bonds
3
Heavy atoms
23

SMILES C1C(N(N=C1C2=CC=C(C=C2)Br)C(=O)CCl)C3=CC=C(C=C3)Br

Computed descriptors from PubChem (CID 3413196), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.