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Chemical structure of VX-509

GC40761

VX-509

Also known as (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide

VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2·5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes

ChemicalCAS944842-54-0MW392.4FormulaC18H19F3N6O
CAS number
944842-54-0
Molecular weight
392.4
Formula
C18H19F3N6O
Solubility
DMF： 25 mg/mL,DMF：PBS (pH 7·2)(1：3)： 0·25 mg/mL,DMSO： 20 mg/mL,Ethanol： 12 mg/mL
InChIKey
ASUGUQWIHMTFJL-QGZVFWFLSA-N
Catalogue number
GC40761
Brand
GLPBIO
Computed properties PubChem CID 59422203 · XLogP 3.1 · TPSA 95.6 Ų · H-bond donors 3
XLogP
3.1
TPSA
95.6 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
28

SMILES CC[C@](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

Computed descriptors from PubChem (CID 59422203), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.