GC12926
VX-745
Also known as 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one
VX-745 (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM
ChemicalCAS209410-46-8MW436.27FormulaC19H9Cl2F2N3OS
- CAS number
- 209410-46-8
- Molecular weight
- 436.27
- Formula
- C19H9Cl2F2N3OS
- Solubility
- ≥ 21·8mg/mL in DMSO
- InChIKey
- VEPKQEUBKLEPRA-UHFFFAOYSA-N
- Catalogue number
- GC12926
- Brand
- GLPBIO
Computed properties PubChem CID 3038525 · XLogP 5.1 · TPSA 70.3 Ų · H-bond donors 0
- XLogP
- 5.1
- TPSA
- 70.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 28
SMILES C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Computed descriptors from PubChem (CID 3038525), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il