Loading...
Chemical structure of VX-765

GC12725

VX-765

Also known as (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide

VX-765 is a newly developed, selective, small molecule caspase-1 inhibitor that can pass the blood-brain barrier and reduce inflammation in vitro and in vivo

ChemicalCAS273404-37-8MW508.99FormulaC24H33ClN4O6
CAS number
273404-37-8
Molecular weight
508.99
Formula
C24H33ClN4O6
Solubility
≥ 313 mg/mL in DMSO, ≥ 50·5 mg/mL in EtOH with ultrasonic
InChIKey
SJDDOCKBXFJEJB-MOKWFATOSA-N
Catalogue number
GC12725
Brand
GLPBIO
Computed properties PubChem CID 11398092 · XLogP 2.3 · TPSA 140 Ų · H-bond donors 3
XLogP
2.3
TPSA
140 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
35

SMILES CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl

Computed descriptors from PubChem (CID 11398092), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.