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Chemical structure of IDH889

GC38640

IDH889

Also known as (4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1)· IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0·02 μM, 0·072 μM and 1·38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively· IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0·014 μM

ChemicalCAS1429179-07-6MW436.48FormulaC23H25FN6O2
CAS number
1429179-07-6
Molecular weight
436.48
Formula
C23H25FN6O2
Solubility
Soluble in DMSO
InChIKey
JDCYIMQAIKEACU-HNAYVOBHSA-N
Catalogue number
GC38640
Brand
GLPBIO
Computed properties PubChem CID 71542286 · XLogP 4.1 · TPSA 93.1 Ų · H-bond donors 1
XLogP
4.1
TPSA
93.1 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
32

SMILES CC1=C(C=CC(=C1)C2=CN=C(N=C2)[C@H](C)NC3=NC=CC(=N3)N4[C@H](COC4=O)C(C)C)F

Computed descriptors from PubChem (CID 71542286), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.