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Chemical structure of IDH305

GC18423

IDH305

Also known as (4R)-4-[(1S)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)-4-pyridinyl]-2-pyridinyl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one

IDH305 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively)

ChemicalCAS1628805-46-8MW490.5FormulaC23H22F4N6O2
CAS number
1628805-46-8
Molecular weight
490.5
Formula
C23H22F4N6O2
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,Ethanol： 30 mg/ml,Ethanol：PBS (pH7·2)(1：20)： 0·05 mg/ml
InChIKey
DCGDPJCUIKLTDU-SUNYJGFJSA-N
Catalogue number
GC18423
Brand
GLPBIO
Computed properties PubChem CID 90415637 · XLogP 3.9 · TPSA 93.1 Ų · H-bond donors 1
XLogP
3.9
TPSA
93.1 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
35

SMILES CC1=CC(=NC=C1C2=CC(=NC=C2)C(F)(F)F)[C@H](C)NC3=NC=CC(=N3)N4[C@H](COC4=O)[C@H](C)F

Computed descriptors from PubChem (CID 90415637), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.