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Chemical structure of IACS-10759 Hydrochloride

GC36286

IACS-10759 Hydrochloride

Also known as 5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole;hydrochloride

IACS-10759 Hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor· IACS-10759 Hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS· IACS-10759 Hydrochloride has the potential for relapsed/refractory AML and solid tumors research

ChemicalCAS1807523-99-4MW599.02FormulaC25H26ClF3N6O4S
CAS number
1807523-99-4
Molecular weight
599.02
Formula
C25H26ClF3N6O4S
Solubility
DMSO： ≥ 100 mg/mL (166·94 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
LUSCFOVOISLXTM-UHFFFAOYSA-N
Catalogue number
GC36286
Brand
GLPBIO
Computed properties PubChem CID 91864637 · TPSA 125 Ų · H-bond donors 1 · H-bond acceptors 12
TPSA
125 Ų
H-bond donors
1
H-bond acceptors
12
Rotatable bonds
7
Heavy atoms
40

SMILES CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F.Cl

Computed descriptors from PubChem (CID 91864637), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.