Loading...
Chemical structure of GKI-1

GC34381

GKI-1

Also known as N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)aniline

GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4·9 and 2·5 ?M against hGWLFL and hGWL-KinDom, respectively· GKI-1 robustly inhibits ROCK1 with an IC50 of 11 ?M, but only weakly affected PKA

ChemicalCAS2444764-03-6MW269.73FormulaC15H12ClN3
CAS number
2444764-03-6
Molecular weight
269.73
Formula
C15H12ClN3
Solubility
DMSO： 200 mg/mL (741·48 mM)
InChIKey
GPXJDHFWTOJHQQ-UHFFFAOYSA-N
Catalogue number
GC34381
Brand
GLPBIO
Computed properties PubChem CID 137333439 · XLogP 4 · TPSA 40.7 Ų · H-bond donors 2
XLogP
4
TPSA
40.7 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
3
Heavy atoms
19

SMILES C1=CC(=CC(=C1)NC2=CC=C(C=C2)Cl)C3=CNN=C3

Computed descriptors from PubChem (CID 137333439), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.