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Chemical structure of GSK2643943A

GC34354

GSK2643943A

Also known as 2-amino-6-[(E)-2-(3-fluorophenyl)ethenyl]-1H-indole-3-carbonitrile

GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20· GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho· GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC)

ChemicalCAS2449301-27-1MW277.3FormulaC17H12FN3
CAS number
2449301-27-1
Molecular weight
277.3
Formula
C17H12FN3
Solubility
DMSO ： ≥ 125 mg/mL (450·78 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
CGXBPMZRTMXEIA-SNAWJCMRSA-N
Catalogue number
GC34354
Brand
GLPBIO
Computed properties PubChem CID 137319705 · XLogP 4.3 · TPSA 65.6 Ų · H-bond donors 2
XLogP
4.3
TPSA
65.6 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
21

SMILES C1=CC(=CC(=C1)F)/C=C/C2=CC3=C(C=C2)C(=C(N3)N)C#N

Computed descriptors from PubChem (CID 137319705), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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