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Chemical structure of GSK2606414

GC17450

GSK2606414

Also known as 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone

GSK2606414 is an orally active, selective protein kinase R-like endoplasmic reticulum kinase (PERK) inhibitor with an IC50 value of 0·4 nM

ChemicalCAS1337531-36-8MW451.44FormulaC24H20F3N5O
CAS number
1337531-36-8
Molecular weight
451.44
Formula
C24H20F3N5O
Solubility
≥ 22·57 mg/mL in DMSO, ≥ 12·03 mg/mL in EtOH with ultrasonic and warming
InChIKey
SIXVRXARNAVBTC-UHFFFAOYSA-N
Catalogue number
GC17450
Brand
GLPBIO
Computed properties PubChem CID 53469448 · XLogP 3.8 · TPSA 77 Ų · H-bond donors 1
XLogP
3.8
TPSA
77 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
33

SMILES CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F

Computed descriptors from PubChem (CID 53469448), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.