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Chemical structure of GDC-0339

GC32958

GDC-0339

Also known as 5-amino-N-[5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0·03 nM, 0·1 nM and 0·02 nM for Pim1, Pim2 and Pim3, respectively· GDC-0339 is discovered as a potential treatment of multiple myeloma

ChemicalCAS1428569-85-0MW465.5FormulaC20H22F3N7OS
CAS number
1428569-85-0
Molecular weight
465.5
Formula
C20H22F3N7OS
Solubility
DMSO ： ≥ 52 mg/mL (111·71 mM)
InChIKey
NHXVGMQFCYBLTL-ZWNOBZJWSA-N
Catalogue number
GC32958
Brand
GLPBIO
Computed properties PubChem CID 73603034 · XLogP 3 · TPSA 143 Ų · H-bond donors 3
XLogP
3
TPSA
143 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
4
Heavy atoms
32

SMILES CN1C(=C(C=N1)NC(=O)C2=C(SC(=N2)C3=C(C=CC=C3F)F)N)N4CC[C@H]([C@@H](CC4)F)N

Computed descriptors from PubChem (CID 73603034), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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