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Chemical structure of GDC-0326

GC19161

GDC-0326

Also known as (2S)-2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide

GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0·2 nM

ChemicalCAS1282514-88-8MW382.42FormulaC19H22N6O3
CAS number
1282514-88-8
Molecular weight
382.42
Formula
C19H22N6O3
Solubility
DMSO ： ≥ 83·3 mg/mL (217·82 mM)
InChIKey
SIKYDKLGPWRPMZ-LBPRGKRZSA-N
Catalogue number
GC19161
Brand
GLPBIO
Computed properties PubChem CID 58204997 · XLogP 1.2 · TPSA 110 Ų · H-bond donors 1
XLogP
1.2
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
28

SMILES C[C@@H](C(=O)N)OC1=CC2=C(C=C1)C3=NC(=CN3CCO2)C4=NC=NN4C(C)C

Computed descriptors from PubChem (CID 58204997), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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