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Chemical structure of GDC-0032

GC17967

GDC-0032

Also known as 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide

GDC-0032 (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0·12 nM, 0·29 nM, 0·97 nM, and 9·1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively

ChemicalCAS1282512-48-4MW460.53FormulaC24H28N8O2
CAS number
1282512-48-4
Molecular weight
460.53
Formula
C24H28N8O2
Solubility
≥ 23·05mg/mL in DMSO
InChIKey
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Catalogue number
GC17967
Brand
GLPBIO
Computed properties PubChem CID 51001932 · XLogP 1.8 · TPSA 119 Ų · H-bond donors 1
XLogP
1.8
TPSA
119 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
34

SMILES CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C

Computed descriptors from PubChem (CID 51001932), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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