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Chemical structure of Inavolisib

GC32710

Inavolisib

Also listed as GDC-0077 (RG6114)

GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0·038 nM)· GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3· GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα

ChemicalCAS2060571-02-8MW407.37FormulaC18H19F2N5O4
CAS number
2060571-02-8
Molecular weight
407.37
Formula
C18H19F2N5O4
Solubility
DMSO ： ≥ 180 mg/mL (441·86 mM)
InChIKey
SGEUNORSOZVTOL-CABZTGNLSA-N
Catalogue number
GC32710
Brand
GLPBIO
Computed properties PubChem CID 124173720 · XLogP 1.5 · TPSA 112 Ų · H-bond donors 2
XLogP
1.5
TPSA
112 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
29

SMILES C[C@@H](C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4[C@@H](COC4=O)C(F)F

Computed descriptors from PubChem (CID 124173720), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.