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Chemical structure of NLRP3 agonist 1

GC26391

NLRP3 agonist 1

Also known as 4-N-(1-methylcyclopropyl)-7-(1H-pyrazol-5-yl)quinazoline-2,4-diamine

NLRP3 agonist 1 (compound 23) is an effective and orally active NLRP3 agonist· NLRP3 agonist 1 can activate Caspase-1 enzyme, cleaving pro-IL-1 β and pro-IL-18 pro-inflammatory cytokines into mature forms

ChemicalCAS2454019-69-1MW280.33FormulaC15H16N6
CAS number
2454019-69-1
Molecular weight
280.33
Formula
C15H16N6
Solubility
DMSO ： 100 mg/mL (356·72 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
KNPJIDCHCYGPIK-UHFFFAOYSA-N
Catalogue number
GC26391
Brand
GLPBIO
Computed properties PubChem CID 154649381 · XLogP 2.2 · TPSA 92.5 Ų · H-bond donors 3
XLogP
2.2
TPSA
92.5 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
21

SMILES CC1(CC1)NC2=NC(=NC3=C2C=CC(=C3)C4=CC=NN4)N

Computed descriptors from PubChem (CID 154649381), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.