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Chemical structure of NLRP3-IN-17

GC71230

NLRP3-IN-17

Also known as 1-[N-cyano-S-(4-methylphenyl)sulfonimidoyl]-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea

NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM

ChemicalCAS2254432-75-0MW394.49FormulaC21H22N4O2S
CAS number
2254432-75-0
Molecular weight
394.49
Formula
C21H22N4O2S
Solubility
DMSO ： 33·33 mg/mL (84·49 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
SOZVZFKPLUXVMT-UHFFFAOYSA-N
Catalogue number
GC71230
Brand
GLPBIO
Computed properties PubChem CID 142490237 · XLogP 5.5 · TPSA 103 Ų · H-bond donors 2
XLogP
5.5
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
28

SMILES CC1=CC=C(C=C1)S(=NC#N)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4

Computed descriptors from PubChem (CID 142490237), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.