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Chemical structure of PF-05221304

GC25726

PF-05221304

Also known as 4-[6-methoxy-4-(7-oxo-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-1'-carbonyl)-2-pyridinyl]benzoic acid

PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL)

ChemicalCAS1370448-25-1MW502.56FormulaC28H30N4O5
CAS number
1370448-25-1
Molecular weight
502.56
Formula
C28H30N4O5
Solubility
DMSO： 100 mg/mL (198·98 mM);Water： Insoluble;Ethanol： 5 mg/mL (9·95 mM)
InChIKey
LXZMHBHEXAELHH-UHFFFAOYSA-N
Catalogue number
GC25726
Brand
GLPBIO
Computed properties PubChem CID 57496611 · XLogP 3.2 · TPSA 115 Ų · H-bond donors 1
XLogP
3.2
TPSA
115 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
37

SMILES CC(C)N1C2=C(CC3(CCN(CC3)C(=O)C4=CC(=NC(=C4)OC)C5=CC=C(C=C5)C(=O)O)CC2=O)C=N1

Computed descriptors from PubChem (CID 57496611), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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