GC18599
PF-05274857 (hydrochloride)
Also known as 1-[4-[5-chloro-4-(3,5-dimethyl-2-pyridinyl)-2-pyridinyl]piperazin-1-yl]-3-methylsulfonylpropan-1-one;hydrochloride
PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5·8 nM and Ki of 4·6 nM· PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway
ChemicalCAS1613439-62-5MW473.4FormulaC20H25ClN4O3S·HCl
- CAS number
- 1613439-62-5
- Molecular weight
- 473.4
- Formula
- C20H25ClN4O3S·HCl
- Solubility
- Soluble in DMSO
- InChIKey
- GULNFUQAVPTTQV-UHFFFAOYSA-N
- Catalogue number
- GC18599
- Brand
- GLPBIO
Computed properties PubChem CID 90489027 · TPSA 91.9 Ų · H-bond donors 1 · H-bond acceptors 6
- TPSA
- 91.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Rotatable bonds
- 5
- Heavy atoms
- 30
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C.Cl
Computed descriptors from PubChem (CID 90489027), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il