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Chemical structure of MK-8719

GC63075

MK-8719

Also known as (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-ethylimino-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol

MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7·9 nM for hOGA) with excellent CNS penetration

ChemicalCAS1382799-40-7MW268.28FormulaC9H14F2N2O3S
CAS number
1382799-40-7
Molecular weight
268.28
Formula
C9H14F2N2O3S
Solubility
DMSO ： 100 mg/mL (372·74 mM; Need ultrasonic)
InChIKey
UDQTXCHQKHIQMH-KYGLGHNPSA-N
Catalogue number
GC63075
Brand
GLPBIO
Computed properties PubChem CID 136416849 · XLogP 0.3 · TPSA 99.4 Ų · H-bond donors 3
XLogP
0.3
TPSA
99.4 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
2
Heavy atoms
17

SMILES CCN=C1N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)C(F)F)O)O

Computed descriptors from PubChem (CID 136416849), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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