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Chemical structure of GDC-0853

GC19162

GDC-0853

Also known as 10-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-pyridinyl]-4,4-dimethyl-1,10-diazatricyclo[6.4.0.02,6]dodeca-2(6),7-dien-9-one

GDC-0853 (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with Kis of 0·91 nM, 1·6, 1·3, 12·6, and 3·4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants· GDC-0853 has the potential for rheumatoid arthritis and systemic lupus erythematosus research

ChemicalCAS1434048-34-6MW664.8FormulaC37H44N8O4
CAS number
1434048-34-6
Molecular weight
664.8
Formula
C37H44N8O4
Solubility
DMSO ： ≥ 23 mg/mL (34·60 mM)
InChIKey
WNEODWDFDXWOLU-QHCPKHFHSA-N
Catalogue number
GC19162
Brand
GLPBIO
Computed properties PubChem CID 86567195 · XLogP 2.3 · TPSA 119 Ų · H-bond donors 2
XLogP
2.3
TPSA
119 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
49

SMILES C[C@H]1CN(CCN1C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=NC=C4)N5CCN6C7=C(CC(C7)(C)C)C=C6C5=O)CO)C8COC8

Computed descriptors from PubChem (CID 86567195), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.