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Chemical structure of PF-06250112

GC34709

PF-06250112

Also known as 5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0·5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0·9 nM and 1·2 nM, respectively

ChemicalCAS1609465-89-5MW438.43FormulaC22H20F2N6O2
CAS number
1609465-89-5
Molecular weight
438.43
Formula
C22H20F2N6O2
Solubility
Soluble in DMSO
InChIKey
SQFDBQCBXUWICP-HNNXBMFYSA-N
Catalogue number
GC34709
Brand
GLPBIO
Computed properties PubChem CID 90118673 · XLogP 3.5 · TPSA 123 Ų · H-bond donors 2
XLogP
3.5
TPSA
123 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
32

SMILES C1C[C@@H](CN(C1)C#N)N2C(=C(C(=N2)C3=CC=C(C=C3)OC4=C(C=C(C=C4)F)F)C(=O)N)N

Computed descriptors from PubChem (CID 90118673), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.