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Chemical structure of PF-05381941

GC63144

PF-05381941

Also known as 1-[3-tert-butyl-1-(3-cyanophenyl)pyrazol-5-yl]-3-(3-methyl-4-pyridin-4-yloxyphenyl)urea

PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively

ChemicalCAS1474022-02-0MW466.53FormulaC27H26N6O2
CAS number
1474022-02-0
Molecular weight
466.53
Formula
C27H26N6O2
Solubility
DMSO ： 100 mg/mL (214·35 mM; Need ultrasonic)
InChIKey
BVCVUQMOUMAXKQ-UHFFFAOYSA-N
Catalogue number
GC63144
Brand
GLPBIO
Computed properties PubChem CID 73212018 · XLogP 5 · TPSA 105 Ų · H-bond donors 2
XLogP
5
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
35

SMILES CC1=C(C=CC(=C1)NC(=O)NC2=CC(=NN2C3=CC=CC(=C3)C#N)C(C)(C)C)OC4=CC=NC=C4

Computed descriptors from PubChem (CID 73212018), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.