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Chemical structure of GLPG0634 analogue

GC17222

GLPG0634 analogue

Also known as N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

GLPG0634 analogue (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of ＜100 nM against JAK1, JAK2 and JAK3

ChemicalCAS1206101-20-3MW410.43FormulaC23H18N6O2
CAS number
1206101-20-3
Molecular weight
410.43
Formula
C23H18N6O2
Solubility
≥ 31·67mg/mL in DMSO with gentle warming
InChIKey
QZXABVVSCDZCLR-UHFFFAOYSA-N
Catalogue number
GC17222
Brand
GLPBIO
Computed properties PubChem CID 44602526 · XLogP 2.8 · TPSA 105 Ų · H-bond donors 1
XLogP
2.8
TPSA
105 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
31

SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)OCC5=CN=C(C=C5)C#N

Computed descriptors from PubChem (CID 44602526), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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