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Chemical structure of CX-5461

GC14404

CX-5461

Also known as 2-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

CX-5461 is a potent and oral rRNA synthesis inhibitor· It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively

ChemicalCAS1138549-36-6MW513.61FormulaC27H27N7O2S
CAS number
1138549-36-6
Molecular weight
513.61
Formula
C27H27N7O2S
Solubility
2 mg/mL in DMF (ultrasound for 5 minutes and heat to 40 ℃)
InChIKey
XGPBJCHFROADCK-UHFFFAOYSA-N
Catalogue number
GC14404
Brand
GLPBIO
Computed properties PubChem CID 25257557 · XLogP 3.3 · TPSA 120 Ų · H-bond donors 1
XLogP
3.3
TPSA
120 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
4
Heavy atoms
37

SMILES CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C

Computed descriptors from PubChem (CID 25257557), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.