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Chemical structure of CX-6258 HCl

GC19747

CX-6258 HCl

Also known as (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one;hydrochloride

CX-6258 HCl is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively

ChemicalCAS1353859-00-3MW498.4FormulaC26H24ClN3O3·HCl
CAS number
1353859-00-3
Molecular weight
498.4
Formula
C26H24ClN3O3·HCl
InChIKey
YYIMMVXTWBIEAG-YHLMHSEJSA-N
Catalogue number
GC19747
Brand
GLPBIO
Computed properties PubChem CID 72201040 · TPSA 65.8 Ų · H-bond donors 2 · H-bond acceptors 4
TPSA
65.8 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
34

SMILES CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl

Computed descriptors from PubChem (CID 72201040), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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